My 2011 E350 and I took a roadtrip to Illinois this weekend. It was an extremely comfortable ride and I was very impressed with the fuel economy. Officially rated at 24 miles per gallon on the highway, my E-Class far exceeded that!
This is my trip odometer on the way up (sorry for the blur): 28.0 MPG @ average speed of 68 for 588 miles.
and this is on the way home:
The final total was 1456 miles at 26.1 MPG! That includes 1300 miles of highway and 156 miles of in town driving. I got close to 500 miles on a single tank before the low fuel indicator lamp was illuminated. I also experienced the Attention Assist notification for the first time. I highly recommend the E-Class for all of you long distance drivers!